A search for potential biomarkers of cardiac allograft rejection using expression profiling of human endomyocardial biopsies
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منابع مشابه
Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft rejection
BACKGROUND Cardiac allograft rejection remains a significant clinical problem in the early phase after heart transplantation and requires frequent surveillance with endomyocardial biopsy. However, this is an invasive procedure, which is unpleasant for the patient and carries a certain risk. Therefore, a sensitive non-invasive biomarker of acute rejection would be desirable. METHODS Endomyocar...
متن کاملMicroRNAs as non-invasive biomarkers of heart transplant rejection.
AIM Rejection is one of the major causes of late cardiac allograft failure and at present can only be diagnosed by invasive endomyocardial biopsies. We sought to determine whether microRNA profiling could serve as a non-invasive biomarker of cardiac allograft rejection. METHODS We included 113 heart transplant recipients from four referral French institutions (test cohort, n = 60, validation ...
متن کاملMolecular Testing for Early Detection and Monitoring of Graft Rejection by Heart Transplant Recipients
Heart transplantation is a life-prolonging procedure for many patients with stage D heart failure and other forms of advanced heart disease. However, even with the latest advances in immunosuppression, graft rejection is a major cause of death among heart transplant patients. It would be desirable to be able to detect rejection early enough and specifically enough to prevent allograft dysfuncti...
متن کاملExpression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection.
BACKGROUND Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for infiltration by CD3(+) T cells and the expression of the chemokine receptors...
متن کاملGene-expression profiling for rejection surveillance after cardiac transplantation.
BACKGROUND Endomyocardial biopsy is the standard method of monitoring for rejection in recipients of a cardiac transplant. However, this procedure is uncomfortable, and there are risks associated with it. Gene-expression profiling of peripheral-blood specimens has been shown to correlate with the results of an endomyocardial biopsy. METHODS We randomly assigned 602 patients who had undergone ...
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